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Dipeptides- Did You Know?

Protein plays a staring role in wound healing.  While the function of protein is well known and researched, less is understood about the role of  collagen.  Collagen has gained popularity for health benefits for a variety of conditions including overall skin health.   The medical community is paying particular attention to its role in the wound healing process.

The body is made up of about 30% collagen.  It is the single most abundant protein in mammals.  While collagen has been used for years as part of topical intervention for wound healing,  not much research has been conducted about its effects when ingested.

So, what do we know?

Collagen naturally contains the dipeptides, prolylhydroxyproline(PO) and hydroxyprolylglycine (OG).  These dipeptides are able to be detected in the blood after ingestion and are resistant to intracellular dipeptide hydrolysis.  Studies suggest that these PO & OG dipeptides play an important role in improving skin barrier dysfunction.  PO has also been found to assist in cell proliferation and induce the synthesis of dermal fibroblasts. All necessities in properly healing a wound.

These concepts are of particular importances as it relates to our new revolutionary wound product, formulated to fast track wound healing.

Expedite is a combination of collagen and L-Citrulline to stimulate collagen synthesis and drive nitric oxide production.  The collagen used in this product has 30 times more PO and OG dipeptides than that of regular collagen, making it essential for nutritional wound intervention.



To learn more about Expedite click HERE



Shoulders, M. D., & Raines, R. T. (2009). Collagen structure and stability. Annual review of biochemistry78, 929–958.
Shimizu J, Asami N, Kataoka A, Sugihara F, Inoue N, Kimira Y, Wada M, Mano H. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun. 2015 Jan 9;456(2):626-30. doi: 10.1016/j.bbrc.2014.12.006. Epub 2014 Dec 8. PMID: 25498544.
Sugihara, F., Inoue, N. & Venkateswarathirukumara, S. Ingestion of bioactive collagen hydrolysates enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study. Sci Rep 8, 11403 (2018).




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